Brain-computer interfaces, also known as neural interfaces, allow people to govern and control their surroundings with just their thoughts. AI Healthtech Startups innovation is the result of years of neuro-engineering study into techniques like electroencephalography (EEG), electrocorticography (ECoG), virtual reality (VR), and augmented reality (AR). As Elon Musk's Neuralink shows, interest in neural interfaces is growing as well. Some new businesses are developing non-invasive brain interfaces for people with disabilities, such as those who are paralyzed or have trouble communicating. Indian newcomer StimVeda is creating a non-invasive brain stimulation device called Ease to help those suffering from depression.

In March 2022 the Mayo Clinic Platform announced their new accelerator program for AI powered health tech startups. The 20 week immersive Mayo Clinic Platform Accelerate Program is designed to help innovative startups establish credibility and get market ready so that they can spark innovation in healthcare. Each company receives a $200,000 benefit package that includes access to Mayo Clinic's rich de-identified data sets, validation frameworks, clinical workflow planning, and mentorship. Startups in the accelerator receive guidance on clinical, regulatory, technology, and business decisions. There are also opportunities for workflow integration and clinical collaboration for research trials, access thought leadership, and peer-reviewed publications.